Detalles de la búsqueda
1.
Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors.
Bioorg Chem;
147: 107383, 2024 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38653151
2.
Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood.
Cell Mol Life Sci;
79(1): 40, 2021 Dec 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-34971430
3.
Development and molecular modeling studies of new thiadiazole piperazine urea derivatives as potential fatty acid amide hydrolase inhibitors.
Arch Pharm (Weinheim);
355(8): e2200082, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-35500130
4.
Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy.
Bioorg Chem;
112: 104861, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33826984
5.
Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol.
J Chem Inf Model;
60(3): 1737-1748, 2020 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32045233
6.
Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors.
Bioorg Chem;
95: 103544, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31915112
7.
Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity.
J Nanobiotechnology;
18(1): 73, 2020 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32408877
8.
Correction: Encapsulation of the dual FLAP/mPEGS1 inhibitor BRP187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity.
J Nanobiotechnology;
22(1): 77, 2024 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-38408973
9.
Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis under Flow Conditions.
Molecules;
24(13)2019 Jul 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31277341
10.
Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents.
J Enzyme Inhib Med Chem;
33(1): 1352-1361, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30251900
11.
Wood's lamp examination of hair and nails related to COVID-19 treatment.
Dermatol Ther;
34(6): e15174, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34694045
12.
Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.
Bioorg Med Chem;
22(12): 3096-104, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24816066
13.
Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer.
Cancer Res;
84(9): 1475-1490, 2024 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38319231
14.
Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors.
ACS Omega;
8(2): 2445-2454, 2023 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36687110
15.
Substituted 1,2,4-Triazoles as Novel and Selective Inhibitors of Leukotriene Biosynthesis Targeting 5-Lipoxygenase-Activating Protein.
ACS Omega;
8(34): 31293-31304, 2023 Aug 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-37663492
16.
Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification.
Cell Death Differ;
30(5): 1305-1319, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36864125
17.
Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer.
bioRxiv;
2023 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37745348
18.
Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).
Bioorg Med Chem;
20(12): 3728-41, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22607880
19.
The 1,2,3-triazole 'all-in-one' ring system in drug discovery: a good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool.
Expert Opin Drug Discov;
17(11): 1209-1236, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36164263
20.
Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors.
ChemMedChem;
17(12): e202200137, 2022 06 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35466565